The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease
スポンサーリンク
概要
- 論文の詳細を見る
Objective To determine the effect of Helicobacter pylori (H. pylori) eradication on blood levels of soluble CD40 ligand, leptin, oxidative stress and body composition in patients with dyspepsia infected with H. pylori. Methods The infection of H. pylori was based on the presence of both 14C urea breath test (UBT) and histology. Patients were given triple eradication therapy for 14 days and at 3 months after the treatment, 14C UBT was reinstituted. Fasting glucose, leptin, body composition, soluble CD40 ligand, total oxidant status (TOS) were studied before and at 3 months after the treatment. Results In 33 subjects, H. pylori infection was successfully eradicated. sCD40L, and TOS levels were significantly decreased after H. pylori eradication. The percentage of body fat and body fat mass significantly decreased whereas the fat free mass (FFM) increased after eradication. However, eradication of the organism yielded no differences in leptin levels. Conclusion These findings suggest that H. pylori eradication reduces the sCD40L and oxidative stress, fat mass with a significant increase in fat free mass. Thus, eradication of H. pylori infection not only improves ulcer healing, but may also reduce the presumed atherosclerosis risk.
著者
-
Kebapcilar Levent
Department of Internal Medicine, Division of Endocrinology and Metabolism, Izmir Bozyaka Training an
-
Yuksel Arif
Department of Internal Medicine, Division of Izmir Bozyaka Training and Research Hospital
-
Sari Ismail
Department Of Hematology Pamukkale University Faculty Of Medicine
-
Alacacioglu Ahmet
Department Of Internal Medicine Dokuz Eylul University School Of Medicine
-
Sari Ismail
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital
-
Alkan Bulent
Department of Internal Medicine, Division of Gastroenterology, Izmir Bozyaka Training and Research Hospital
-
Renkal Ali
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital
-
Ilhan Enver
Department of Surgery, Izmir Bozyaka Training and Research Hospital
-
Yuksel Diydem
Department Nuclear Medicine, Izmir Bozyaka Training and Research Hospital
-
Kozaci Didem
Department of Biochemistry, Adnan Menderes University School of Medicine
-
Gunay Necati
Department of Biochemistry, Adnan Menderes University School of Medicine
関連論文
- Subclinical Hypercortisolism among Polycythemia Vera Patients
- Comparison of 1 mg and 2 mg Overnight Dexamethasone Suppression Tests for the Screening of Cushings Syndrome in Obese Patients
- The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease
- HDR Syndrome (Hypoparathyroidism, Sensorineural Deafness and Renal Disease) Accompanied by Renal Tubular Acidosis and Endocrine Abnormalities
- Thyrotoxic Periodic Paralysis in a Turkish Male ; The Recurrence of the Attack after Radioiodine Treatment
- Multiple myeloma presenting with acquired factor VIII inhibitor
- Evaluation of inflammation and oxidative stress in ankylosing spondylitis : a role for macrophage migration inhibitory factor
- The First Documented Case of Brucellosis Manifested with Pancytopenia and Capillary Leak Syndrome