Complex Formation of a Brain-Derived Neurotrophic Factor and Glycosaminoglycans

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概要

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• Glycosaminoglycans (GAGs), large anionic glycopolymers, are the glycan portion of proteoglycans and are important components of the extracellular matrix. Recently we reported that polysialic acid, a polyanionic glycopolymer specific to the brain, binds neurotrophic factors to form a large complex. It is not clear whether GAGs also bind neurotrophic factors to form a large complex. In the present study, we demonstrate that a brain-derived neurotrophic factor (BDNF) dimer directly binds GAGs other than chondroitin and hyaluronic acid to form a large complex. Neurotrophin-3 showed similar GAG binding properties. Furthermore, BDNF, after forming a large complex with GAG, bound to the BDNF receptors tropomyosin-related kinase (Trk) B and p75 neurotrophin receptor (NTR). These findings suggest that GAGs function to produce a reservoir of BDNF and other neurotrophic factors, and may serve to regulate their local concentrations on the cell surface.

• 社団法人 日本農芸化学会の論文

著者

• Sato Chihiro

  Graduate School of Bioagricultural Sciences, Nagoya University

• Kitajima Ken

  Graduate School of Bioagricultural Sciences, Nagoya University

• Kitajima Ken

  Graduate School Of Bioagricultural Sciences And The Bioscience And Biotechnology Center Nagoya Unive

• KANATO Yukihiro

  Graduate School of Bioagricultural Sciences and the Bioscience and Biotechnology Center, Nagoya Univ

• ONO Sayaka

  Graduate School of Bioagricultural Sciences and the Bioscience and Biotechnology Center, Nagoya Univ

関連論文

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• THE 130 KDA GLYCOPROTEIN IS SECRETED FROM SPERM DURING ACROSOME REACTION OF SEA URCHIN, HEMICENTROTUS PULCHERRIMUS(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• SEA URCHIN SPERM FLAGELLA CONTAINS GLYCOPROTEIN WITH α2→9-LINKED POLYSIALIC ACID CHAINS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• CAPACITATION-INDUCED CHANGES OF THE SURFACE DISTRIBUTION OF SIALOGLYCOTOPES ON PIG SPERM(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
• CELL GROWTH STIMULATING ACTIVITY OF THE PEPTIDES DERIVED FROM CORTICAL ALVEOLUS GLYCOPROTEINS OF FISH EGG (HYOSOPHORIN)(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• A MAJOR GANGLIOSIDE FROM HEMICENTROTUS PULCHERRIMUS SPERM SPECIFICALLY INTERACTS WITH PHOSPHOLIPIDS(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• Complex Formation of a Brain-Derived Neurotrophic Factor and Glycosaminoglycans
• Complex Formation of a Brain-Derived Neurotrophic Factor and Glycosaminoglycans

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