A Comparative Analysis of Metabolic Pathways Based on Metabolic Steady States

スポンサーリンク

概要

• 論文の詳細を見る

• A comparative analysis of organisms with metabolic pathways provides important information about functions within organisms. In this paper, we discuss problem of comparing organisms using partial metabolic structures that contain many biological characteristics and propose a pathway comparison method based on an elementary flux mode (EFM) — the minimal metabolic pathway that satisfies a steady state. By the extraction of the 'elementary flux mode, ' we obtain biologically significant metabolic substructures. To compare metabolic pathways based on EFMs, we propose a new pseudo alignment method with a penalty based on the importance of enzymes. The distance among organisms can be calculated based on the pseudo alignment of EFMs. To confirm its effectivity, we apply the proposed method to the pathway datasets from 38 organisms. We successfully reconstructed a "three domain theory" from the aspect of the biological function. Moreover, we evaluated the results in terms of the accuracy of organism classification from the biological function and confirmed that the obtained classification was related deeply to such habitats as aerobe or anaerobe.

• Information and Media Technologies 編集運営会議の論文

著者

• OHKAWA Takenao

  Kobe University

• Ozaki Tomonobu

  Kobe University

• Ashida Yuta

  Kobe University

関連論文

• Entity Network Prediction Using Multitype Topic Models
• A Method to Extract Sentences with Protein Functional Information from Literature by Iterative Learning of the Corpus
• Erratum: Entity Network Prediction Using Multitype Topic Models [IEICE Transactions on Information and Systems E91.D (2008) , No. 11 pp.2589-2598]
• A Method to Extract Sentences with Protein Functional Information from Literature by Iterative Learning of the Corpus
• A Comparative Analysis of Metabolic Pathways Based on Metabolic Steady States

スポンサーリンク