Hepatitis C virus utilizes lipid droplet for production of infectious virus

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概要

• 論文の詳細を見る

• Hepatitis C virus (HCV) establishes a persistent infection and causes chronic hepatitis. Chronic hepatitis patients often develop hepatic cirrhosis and progress to liver cancer. The development of this pathological condition is linked to the persistent infection of the virus. In other words, viral replication/multiplication may contribute to disease pathology. Accumulating clinical studies suggest that HCV infection alters lipid metabolism, and thus causes fatty liver. It has been reported that this abnormal metabolism exacerbates hepatic diseases. Recently, we revealed that lipid droplets play a key role in HCV replication. Understanding the molecular mechanism of HCV replication will help elucidate the pathogenic mechanism and develop preventive measures that inhibit disease manifestation by blocking persistent infection. In this review, we outline recent findings on the function of lipid droplets in the HCV replication cycle and describe the relationship between the development of liver diseases and virus replication.(Communicated by Takao SEKIYA, M.J.A.)

• 日本学士院の論文

著者

• OGAWA Kazuya

  Research Institute, Chiba Institute of Technology

• HISHIKI Takayuki

  Research Institute, Chiba Institute of Technology

• SHIMIZU Yuko

  Research Institute, Chiba Institute of Technology

• FUNAMI Kenji

  Research Institute, Chiba Institute of Technology

• SUGIYAMA Kazuo

  Center for Integrated Medical Research, Keio University

• MIYANARI Yusuke

  Division of Human Genetics, National Institute of Genetics

• SHIMOTOHNO Kunitada

  Research Institute, Chiba Institute of Technology

関連論文

• Hepatitis C virus utilizes lipid droplet for production of infectious virus

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