Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid β-induced Damage In Vivo and In Vitro
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to determine the effects of Wu-Zi-Yan-Zong-Fang on amyloid-β25-35-induced cognitive deficits in rats and neurotoxicity in pheochromocytoma cells and the possible mechanism of action. In vivo studies showed that Wu-Zi-Yan-Zong-Fang significantly ameliorated the spatial memory and retention deficits, decreased acetylcholinesterase activity, and increased acetylcholine content caused by intracerebroventricular injection of amyloid-β25-35. In vitro results showed that Wu-Zi-Yan-Zong-Fang increased cell viability and the activity of superoxide dismutase and catalase and decreased the release of lactate dehydrogenase and the level of malondialdehyde. Wu-Zi-Yan-Zong-Fang also significantly reduced the percentage of apoptotic cells and blocked the increase in the intracellular concentration of Ca2+. These data suggest that Wu-Zi-Yan-Zong-Fang has potent protective effects for the treatment of Alzheimers disease in future.
- 公益社団法人 日本薬学会の論文
著者
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WANG Bin
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospit
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WANG Xue
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospit
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FU Hong
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospit
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LIU Geng
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospit
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FU Hong
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospital
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LIU Geng
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospital
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WANG Xue
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospital
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WANG Bin
Institute of Integration of Traditional Chinese and Western Medicine, Peking University First Hospital
関連論文
- Protective Effects of Wu-Zi-Yan-Zong-Fang on Amyloid β-induced Damage In Vivo and In Vitro
- Cloning, Characterization and Expression Analysis of Calcium Channel β Subunit from Pearl Oyster(Pinctada fucata)(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Multi-dimensional population balance modeling of the growth of rod-like L-glutamic acid crystals using growth rates estimated from in-process imaging