Cerebral Metabolism in Dogs Assessed by 18F-FDG PET: A Pilot Study to Understand Physiological Changes in Behavioral Disorders in Dogs

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Positron Emission Tomography (PET) imaging technique which is utilized in human behavior and psychiatric disorder research, was performed on brains of clinically normal mixed breed dogs; 3 hound type (long floppy ears) mixed breed dogs and 3 non-hound retriever type mixed breed dogs. Glucose metabolism was obtained with F-18 fluorodeoxyglucose (FDG) and quantitative analysis was done by standardized uptake value (SUV) measurement. Magnetic Resonance (MR) Images were obtained in each dog and these images were superimposed to PET images to identify anatomical locations. The glucose metabolism in each ROIs was compared between the three hound type dogs and 3 non-hound type dogs. Two anatomically different type dogs were compared to assessment of whether breed-typical behavioral tendencies (e.g., sniffing behavior in hound type dogs, staring and retrieving in Labrador type dogs) are reflected in baseline brain metabolic activity. There were no significant differences between hound type dogs and non-hound type dogs in cerebral SUV values. These data might serve as normal canine cerebral metabolism data for FDG PET studies in dogs and form basis for investigations into behavioral disorders in dogs such as compulsive disorder, anxiety disorders, and cognitive dysfunction.