Extended X-Ray Absorption Fine Structure Study on Reaction of Anti-tumor Platinum Complexes with Reduced Glutathione

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概要

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• Reactions of cis-diamminedichloroplatinum(II) (cisplatin) and 1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) with reduced glutathione, a tripeptide that is abundant in cells, were studied by means of X-ray absorption spectroscopy. Back-scattering amplitudes Fi(k) and phase shifts Φi(k) were theoretically derived, and validated by applying them to calculate extended X-ray absorption fine structure (EXAFS) oscillations of cisplatin and K2[Pt(SCN)4] in the solid state. EXAFS oscillations of reaction mixtures of cisplatin or carboplatin with reduced glutathione were fitted to the standard EXAFS equation using the Fi(k) and Φi(k) functions to give the coordination numbers of N or O atoms (NN/O) and of Cl or S atoms (NCl/S). For both cisplatin and carboplatin, the NN/O value decreased and the NCl/S values increased monotonically as the reaction proceeded. However, the reaction rate for carboplatin was significantly slower than that for cisplatin.

• 公益社団法人　日本薬学会の論文

著者

• HIROHARA Shiho

  Graduate School of Materials Science, Nara Institute of Science and Technology

• YANO Shigenobu

  Endowed Research Section, Photomedical Science, Innovative Collaboration Center, Kyoto University

• Obata Makoto

  Graduate School of Humanities and Sciences, Nara Womens University

• Harada Masafumi

  Faculty of Human Life and Environment, Nara Womens University

• Ohi Hiromi

  Endowed Research Section, Photomedical Science, Innovative Collaboration Center, Kyoto University

• Gottchaldt Michael

  Institute for Organic and Macromolecular Chemistry, Friedrich Schiller University of Jena

• Yano Shigenobu

  Endowed Res. Section Photomedical Sci. Innovative Collaboration Center Kyoto Univ.

• Hirohara Shiho

  Graduate School Of Materials Sci. Nara Inst. Of Sci. And Technol.

• Obata Makoto

  Interdisciplinary Graduate School Of Medicine And Engineering University Of Yamanashi

• Harada Masafumi

  Faculty of Human Life and Environment, Nara Women's University

• Obata Makoto

  Graduate School of Humanities and Sciences, Nara Women's University

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