Practical Large Scale Synthesis of Half-Esters of Malonic Acid

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概要

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• A practical large-scale synthesis of monomethyl malonate and monoethyl malonate, which are among the most commonly applied half-esters in organic synthesis, is described, applying the highly efficient selective monohydrolysis of symmetric diesters we reported before. The optimal conditions with regard to the type of base, equivalent, co-solvents, and the reaction time have been examined for large-scale reactions. Monomethyl malonate and monoethyl malonate were obtained in high yields with near 100% purity within only half a day. The conditions of this selective monohydrolysis reaction are environmentally benign and straightforward, as it requires only water, a small proportion of a volatile co-solvent, and inexpensive reagents, and produces no hazardous by-products, and therefore the synthetic utility of this reaction in process chemistry is expected.

• 公益社団法人　日本薬学会の論文

著者

• NIWAYAMA Satomi

  Departments of Biology and Chemistry, Center for Cancer Research, Massachusetts Institute of Technol

• Niwayama Satomi

  Department Of Chemistry And Biochemistry Texas Tech University

• Cho Hanjoung

  Department of Chemistry and Biochemistry, Texas Tech University

• Cho Hanjoung

  Department Of Chemistry And Biochemistry Texas Tech University

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