A Facile Method for Preparation of [2H3]-Sufentanil and Its Metabolites

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概要

• 論文の詳細を見る

• An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.

• 公益社団法人　日本薬学会の論文

著者

• Srimurugan Sankareswaran

  Department of Chemistry, National Dong Hwa University

• Murugan Kaliyappan

  Department of Chemistry, National Dong Hwa University

• Chen Chinpiao

  Department of Chemistry, National Dong Hwa University

• Chen Chinpiao

  Department Of Chemistry National Dong Hwa University

関連論文

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