Synthesis and Evaluation of Different Fatty Acid Esters Formulated into Precirol® ATO-Based Lipid Nanoparticles as Vehicles for Topical Delivery

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概要

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• A series of isopropyl fatty esters having different chain length (C13—C23) were synthesized and formulated in lipid nanoparticles based on Precirol® ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by high shear homogenization method, had a mean diameter ranging from 180 to 280 nm and showed an encapsulation efficiency of about 100%. Ex vivo permeation results demonstrated a parabolic correlation between permeation effect and chain length of the fatty esters present in the lipid nanoparticles formulated in hydrophilic gels. The maximum flux of drug was observed for the nanoparticles containing esters with 17 and 19 carbon atoms, suggesting that these formulations may constitute a potential carrier for topical delivery of econazole nitrate.

• 公益社団法人　日本薬学会の論文

著者

• Sanna Vanna

  Prion DGN c/o Porto Conte Research Centre

• Mariani Alberto

  Department of Chemistry and Local INSTM Unit, University of Sassari

• Caria Giuseppe

  Department of Chemistry and Local INSTM Unit, University of Sassari

• Sechi Mario

  Dipartimento Farmaco Chimico Tossicologico, University of Sassari

関連論文

• Synthesis and Evaluation of Different Fatty Acid Esters Formulated into Precirol® ATO-Based Lipid Nanoparticles as Vehicles for Topical Delivery

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