Three New 7.3′,8.5′-Connected Bicyclo[3.2.1]octanoids and Other Neolignans from Leaves of Nectandra amazonum NEES. (Lauraceae)

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概要

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• Three new 7.3′,8.5′-connected (macrophyllin-type) bicyclo[3.2.1]octanoid neolignans (nectamazins A—C, 1—3) were isolated from leaves of Nectandra amazonum NEES., along with seven known neolignans (4—10). The structures of 1—3 were characterized by spectroscopic methods (1D, 2D NMR) and the absolute configuration was assigned on the basis of circular dichroism (CD) spectra supported by nuclear Overhauser effect spectroscopy (NOESY) correlations. The new compounds showed inhibition activity against platelet activating factor (PAF)-induced aggregation of rabbit platelets.

• 社団法人 日本薬学会の論文

著者

• Coy Barrera

  Universidad Nacional De Colombia Facultad De Ciencias Departamento De Quimica Laboratorio De Investi

• Cuca Suarez

  Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Inve

関連論文

• Three New 7.3′,8.5′-Connected Bicyclo[3.2.1]octanoids and Other Neolignans from Leaves of Nectandra amazonum NEES. (Lauraceae)
• seco-Limonoids and Quinoline Alkaloids from Raputia heptaphylla and Their Antileishmanial Activity

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