Preparation and Evaluation of Gastroretentive Floating Tablets of Silymarin
スポンサーリンク
概要
- 論文の詳細を見る
The present study performed by preparation and evaluation of floating tablets of Silymarin as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate and citric acid and evaluated for floating properties, swelling characteristics and in vitro drug release studies. Floating noneffervescent tablets were prepared by polypropylene foam powder and different matrix forming polymers like HPMC K 4M, Carbopol 934P, xanthan gum and sodium alginate. In vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow both the Higuchi and the Korsemeyer and Peppas equation. The drug release mechanism was found fickian type in most of the formulations. The developed floating tablets of Silymarin may be used in clinic for prolonged drug release for at least 24 h, thereby improving the bioavailability and patient compliance.
- 公益社団法人 日本薬学会の論文
著者
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Garg Rajeev
Department of Pharmaceutics, ASBASJSM College of Pharmacy
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Gupta Ghanshyam
Department of Pharmaceutics, ASBASJSM College of Pharmacy
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Garg Rajeev
Department Of Chemical Engineering Indian Institute Of Technology
関連論文
- Modeling and Simulation of a Non-Isothermal Tubular Thermal Cracker
- Preparation and Evaluation of Gastroretentive Floating Tablets of Silymarin