Cytotoxic Geranylated Xanthones and O-Alkylated Derivatives of α-Mangostin

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概要

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• Two new geranylated xanthones, 6-O-methylcowanin (4) and oliverixanthone (5), along with five known compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, and β-mangostin, have been isolated from the bark of Garcinia oliveri. For comparison of their biological activities, one mono- and seven di-O-alkylated α-mangostin derivatives were synthesized from α-mangostin. The structures of all compounds were assigned by spectroscopic methods (1D and 2D NMR and MS). Cytotoxicity of selected xanthones against MCF-7 and DLD-1 cell lines was examined. Evaluation of the structure–activity relationship showed that α-mangostin had the strongest activity, and all the O-alkylated α-mangostin derivatives showed reduced activity compared to the naturally occurring α-mangostin.

著者

• Ha Ly

  Faculty of Chemistry, HCM City University of Natural Sciences

• Hansen Poul

  Department of Science, Systems and Models, Roskilde University

• Vang Ole

  Department of Science, Systems and Models, Roskilde University

• Duus Fritz

  Department of Science, Systems and Models, Roskilde University

• Pham Hung

  Faculty of Chemistry, HCM City University of Natural Sciences

• Nguyen Lien-Hoa

  Faculty of Chemistry, HCM City University of Natural Sciences

• Duus Fritz

  Department Of Life Sciences And Chemistry Roskilde University

• Vang Ole

  Dep. Of Sci. Systems And Models Roskilde Univ.

関連論文

• Cytotoxic Geranylated Xanthones and O-Alkylated Derivatives of α-Mangostin
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