Severe Myelosuppression Following Alopecia Shortly after the Initiation of 6-Mercaptopurine in a Patient with Crohn's Disease

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概要

• 論文の詳細を見る

• A 15-year-old, woman, Crohn's disease patient, who carried the TPMT *3C heterozygous mutant, complained of alopecia 3 days after starting 6-mercaptopurine (6-MP) and then developed severe myelosuppression 6 weeks after starting 6-MP. The alopecia involved scalp hair only (body hair preserved) and was dominant in the temporal region. Following these side effects, transient remission of Crohn's disease occurred. Myelosuppression due to 6-MP is a rare but life-threatening side effect that is difficult to predict despite continuous monitoring of complete blood cell counts. In the present case, 6-MP-induced alopecia preceded myelosuppression and progressed rapidly as the myelosuppression worsened.

• 社団法人 日本内科学会の論文

著者

• Ushimaru Shinya

  Division of Gastroenterology, Jichi Medical University, Saitama Medical Center

• Miyatani Hiroyuki

  Division of Gastroenterology, Jichi Medical University, Saitama Medical Center

• Nakashima Yoshiyuki

  Division of Gastroenterology, Jichi Medical University, Saitama Medical Center

関連論文

• Severe Myelosuppression Following Alopecia Shortly after the Initiation of 6-Mercaptopurine in a Patient with Crohn's Disease

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