Transfusion-Related Acute Lung Injury (TRALI) Induced by Donor-Derived Anti-HLA Antibodies in Aplastic Anemia: Possible Priming Effect of Granulocyte-Colony Stimulating Factor (G-CSF) on the Recipient Neutrophils
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概要
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Transfusion-related acute lung injury (TRALI) is currently the leading cause of transfusion-related death. A 67-year-old man with severe aplastic anemia developed TRALI, consisting of acute respiratory insufficiency with severe hypoxia and diffuse pulmonary infiltration 2 hours after the transfusion of platelet concentrates. Although he required intensive respiratory support, he promptly recovered within 4 days. The presence of anti-HLA antibody (anti-HLA B52) in the donated blood product was demonstrated, and a lymphocytotoxicity test disclosed antibody-mediated cytotoxicity against the patients cells. Furthermore, administration of granulocyte-colony stimulating factor was suggested to predispose the patient to TRALI by priming the neutrophils.
著者
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Hishizawa Masakatsu
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Ohno Tatsuharu
Division Of Hematology And Immunology Department Of Internal Medicine Ohtsu Red Cross Hospital
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Mitsuhashi Ryuichi
Division of Transfusion Medicine and Cell Therapy, Department of Laboratory Medicine, Ohtsu Red Cross Hospital
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