Neuroaspergillosis in an Immunocompetent Patient Successfully Treated with Voriconazole and a Corticosteroid

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概要

• 論文の詳細を見る

• Aspergillosis of the central nervous system (CNS) is an uncommon infection, mainly occurring in immunocompromised patients. We report a case of nasocerebral aspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid. Magnetic resonance imaging (MRI) showed contrast enhancement surrounding the brainstem and cerebellum with intramedullary pontine and cerebellar T2-hyperintense lesions. The patients symptoms and MRI abnormalities improved after voriconazole and corticosteroid treatment; however, discontinuation of the corticosteroid caused a worsening of the T2-hyperintense lesions, whereas resuming it resulted in its improvement. This suggested that these T2-hyperintense lesions may be due to secondary inflammation caused by aspergillosis and not the aspergillosis itself. We conclude that treatment with a combination of voriconazole and a corticosteroid appears to be effective for the treatment of some patients with CNS aspergillosis.

著者

• Numata Tsutomu

  Department of Otology, National Hospital Organization Chiba Medical Center

関連論文

• Neuroaspergillosis in an Immunocompetent Patient Successfully Treated with Voriconazole and a Corticosteroid

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