Improvement of Cardiac Function after Granulocyte-colony Stimulating Factor-mobilized Peripheral Blood Mononuclear Cell Implantation in a Patient with Non-ischemic Dilated Cardiomyopathy Associated with Thromboangiitis Obliterans

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概要

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• Cardiac involvement is a rare complication with thromboangiitis obliterans (TAO). We report a 29-year-old man with TAO accompanied with non-ischemic dilated cardiomyopathy. He had no history of heart disease, but echocardiogram demonstrated diffuse hypokinesis and dilated left ventricle. Coronary angiography revealed no organic stenotic lesion. For limb salvage, he was treated with granulocyte-colony stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cell (PBMNC) implantation on his right leg. Not only ischemic leg symptoms, but also plasma level of BNP and 123I-metaiodobenzylguanidine scintigraphic parameters improved after 24 weeks. G-CSF-mobilized PBMNC implantation could be an effective approach to treating non-ischemic cardiomyopathy.

著者

• Kakihana Ayano

  Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine

• Takishita Shuichi

  Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine

• Kamiyama Tomomasa

  Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine

• Ishiki Tetsuya

  Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine

関連論文

• Improvement of Cardiac Function after Granulocyte-colony Stimulating Factor-mobilized Peripheral Blood Mononuclear Cell Implantation in a Patient with Non-ischemic Dilated Cardiomyopathy Associated with Thromboangiitis Obliterans

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