Intervals between Symptom Onset and Clinical Presentation in Cancer Patients
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概要
- 論文の詳細を見る
Objective We aimed to investigate relative values of the intervals between symptom onset and clinical presentation in cancer patients and to correlate them with diagnosis of distant metastasis. Methods Cancer registry and medical records of all cancer patients for over a 10-year period in a medical center of Japan were reviewed. We examined the intervals of symptom onset to clinical presentation and the presence of metastasis at diagnosis. Results In 3,893 cancer patients, the mean interval of symptom onset to clinical presentation was 89 days (median, 30 days). The cancer group with a short interval of only days to weeks included hepatobiliary, ovary, brain, and acute leukemia. The group with a long interval of months to years included head and neck, thyroid, and skin cancers. Other types of cancer were included in the middle group with an interval of weeks to months. Among patients with head & neck, skin, and ovarian cancers, the longer interval was significantly associated with a lower likelihood of distant metastasis. A longer interval with an increment of each month was associated with a lower likelihood for distant metastasis with an odds ratio of 0.97 (95% CI, 0.96-0.99). Conclusion Hepatobiliary, ovary, brain, and acute leukemia are among the cancer types with an interval of days to weeks, while head and neck, thyroid, and skin cancers are among the types with an interval of months to years. Among patients with solid tumors, those with metastasis are likely to present to a physician more promptly.
- 社団法人 日本内科学会の論文
著者
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Tokuda Yasuharu
聖ルカ・ライフサイエンス研究所 臨床疫学センター
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Tokuda Yasuharu
Center for Clinical Epidemiology, St. Lukes Life Science Institute
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Chinen Katsuya
Department of Pathology, Kyorin University School of Medicine
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Obara Haruo
Department of Medicine, Okinawa Chubu Hospital
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Joishy Suresh
Department of Oncology, Kaiser Permanente Fresno Medical Center
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Tokuda Yasuharu
Center For Clinical Epidemiology St. Luke's Life Science Institute
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Chinen Katsuya
Department Of Gastroenterology And Hepatology Saitama Medical Center Saitama Medical University
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Tokuda Yasuharu
Center for Clinical Epidemiology, St. Luke's Life Science Institute
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