Developed Force of Papillary Muscle : What Index Correctly Indicates Contractile Capacity?

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概要

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• We hypothesized that similar samples of the same normal heart should report similar contractile index values. We analyzed anterior (AP) and posterior (PP) papillary muscles (PM) of the same heart (n = 46), whose representation of force fulfills this premise calculating force (F: mN), tension (T: mN/mm2), and tension per milligram of myocardium (δ: mN/mm2/mg). In all analyses, F and +dF/dt as well as T and dT/dt values were higher in heavier PM. These differences disappeared for δ and dδ/dt. There was a significant and positive correlation for F and T as well as its derivative with myocardial mass. Myocardial depression (verapamil) of PP, in comparison to AP, was not recognized by F or T, but was identified when reported as δ. We conclude that the normalization of tension for papillary muscle mass is the most appropriate form for reporting intrinsic contractile capacity in PM since F and T depend on the myocardial mass participating in contraction.

著者

• Bocalini Danilo

  Division of Internal Medicine, Federal University of São Paulo

• Tucci Paulo

  Division of Cardiology, Federal University of São Paulo

関連論文

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• Developed Force of Papillary Muscle : What Index Correctly Indicates Contractile Capacity?

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