Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-.GAMMA. Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men Interaction With Smoking Status:Interaction With Smoking Status

スポンサーリンク

概要

• 論文の詳細を見る

• Background: The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-γ (PPARG), has been robustly associated with type 2 diabetes. However, its role in metabolic syndrome (MetS) remains poorly understood. The associations among rs1801282, MetS and surrogate measures of insulin resistance (IR) were investigated in the present study. Methods and Results: A cross-sectional population-based survey of 572 unrelated healthy male Argentinian blood donors with normal findings on medical examination and not taking any medication was conducted. MetS was assessed using the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) criteria, and the HOMA-IR, and QUICKI were calculated. Genotyping of rs1801282 was performed using RFLP-PCR. The prevalence of MetS was 26.2%. The Pro/Ala genotype (and the Ala12 allele) was associated with a high risk for MetS (odds ratio (OR) 1.67 [95% confidence interval (CI) 1.03-2.72], P=0.0394). This was highlighted among nonsmokers (OR 2.20 [95%CI 1.25-3.88], P=0.0059). ANCOVA confirmed an interaction between smoking status and this association (P=0.031). Ala12 carriers had a higher waist circumference than noncarriers (P=0.0065). Among nonsmokers, surrogates of IR, such as HOMA-IR, were significantly higher in Ala12 carriers than in noncarriers (P<0.05). Conclusions: Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. (Circ J 2009; 73: 2118-2124)

• 一般社団法人 日本循環器学会の論文

著者

• Frechtel Gustavo

  Laboratory Of Molecular Biology Department Of Genetics And Molecular Biology School Of Pharmacy And

• Cerrone Gloria

  Laboratory Of Molecular Biology Department Of Genetics And Molecular Biology School Of Pharmacy And

• Perez Maria

  Laboratorio De Optica Departamento De Fisica Aplicada Escola De Optica E Optometria E Facultade De F

• Taverna Mariano

  Division Of Diabetology Hospital "jose De San Martin" University Of Buenos Aires

• Tellechea Mariana

  Laboratory Of Molecular Biology Department Of Genetics And Molecular Biology School Of Pharmacy And

• Aranguren Florencia

  Division Of Diabetology Hospital "jose De San Martin" University Of Buenos Aires

関連論文

• Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men : Interaction With Smoking Status
• Non-Paraxial Diffraction-Free Propagation of Light in a Graded-Index Planar Waveguide with Hyperbolic Secant Refractive Index Profile
• Pro12Ala Polymorphism of the Peroxisome ProliferatorActivated Receptor-.GAMMA. Gene is Associated With Metabolic Syndrome and Surrogate Measures of Insulin Resistance in Healthy Men Interaction With Smoking Status:Interaction With Smoking Status

スポンサーリンク