Some Cyclin-Dependent Kinase Inhibitors-Related Genes Are Regulated by Vitamin C in a Model of Diet-Induced Obesity

スポンサーリンク

概要

• 論文の詳細を見る

• The aim of this research was to investigate differential gene expression of cyclin-dependent kinase inhibitors (CKIs) in white adipose tissue (WAT) and liver from high-fat fed male Wistar rats with or without vitamin C (VC) supplementation (750 mg/kg of body weight). After 56 d of experimentation, animals fed on a cafeteria diet increased significantly body weights and total body fat. Reverse transcription-polymerase chain reaction (RT-PCR) studies showed that cafeteria diet decreased p21 and p57 mRNA expression in subcutaneous WAT and increased p21 mRNA in liver. Overall, these data provide new information about the role of high fat intake on mRNA levels of several CKIs with implications in adipogenesis, cell metabolism and weight homeostasis. Interestingly, VC supplementation partially prevented diet-induced adiposity and increased p27 mRNA in liver without any changes in the other tissues and genes analyzed. Thus, hepatic mRNA changes induced by ascorbic acid indicate a possible role of these genes in diet-induced oxidative stress processes.

著者

• Boque Noemi

  Institute of Nutrition and Food Science, University of Navarra

• Campion Javier

  Institute of Nutrition and Food Science, University of Navarra

• Milagro Fermin

  Institute of Nutrition and Food Science, University of Navarra

• Moreno-Aliaga Maria-Jesús

  Institute of Nutrition and Food Science, University of Navarra

• Martinez José

  Institute of Nutrition and Food Science, University of Navarra

• Martinez José

  Institute of Nutrition and Food Science, University of Navarra

関連論文

• Some Cyclin-Dependent Kinase Inhibitors-Related Genes Are Regulated by Vitamin C in a Model of Diet-Induced Obesity
• High-Performance CMOS Building blocks for Hearing Aid Devices

スポンサーリンク