The Alleviating Pain Effect of Aqueous Extract from Tong-Xie-Yao-Fang, on Experimental Visceral Hypersensitivity and Its Mechanism

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概要

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• Tong-Xie-Yao-Fang (TXYF) is a prescription in traditional chinese medicine (TCM), used for relieving abdominal pain associated with irritable bowel syndrome. The aim of the present study was to investigate the effects and mechanism of TXYF on experimental visceral hypersensitivity (VH) models. TXYF affected the abdominal withdrawal reflex produced by colonic distention in maternal separation-induced visceral hypersensitivity rats, in a dosage-dependent manner. TXYF significantly decreased serotonin (5-HT) levels in serum and corticotrophin releasing factor (CRF) concentrations in the brain. Moreover, it was found that VH alleviation by TXYF was dependent on the substance P (SP) expression in the colon mucosa. These results suggest that TXYF attenuates behavioral hyperalgesia by regulating substance associated with the brain–gut axis, including decreasing the expression of 5-HT and SP in the periphery and that of CRF in the center.

• 公益社団法人　日本薬学会の論文

著者

• Hu Xu-Guang

  Guangdong Pharmaceutical University

• Xu Di

  Guangdong Pharmaceutical University

• Zhao Yue

  Guangdong Pharmaceutical University

• Yang Xiang-Bo

  MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal Uni

• Meng Jiang

  Guangdong Pharmaceutical University

• Shen Han

  Guangdong Pharmaceutical University

• Guo Jiao

  Guangdong Pharmaceutical University

関連論文

• The Alleviating Pain Effect of Aqueous Extract from Tong-Xie-Yao-Fang, on Experimental Visceral Hypersensitivity and Its Mechanism

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