11-Tungstophosphate with Iron(II) and Hydrogen Peroxide Efficiently Detached Bacterial Biofilm

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概要

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• An attempt was made to detach bacterial biofilm, formed by Staphylococcus epidermidis, by using hydrogen peroxide (H2O2) and tungsten compounds. When iron(II) (Fe2+) was mixed with undecatungstophosphate ([PW11O39]7−) and then H2O2, the resulting mixture was able to totally remove the biofilm probably because of co-generation of 1O2 and ·OH. A mixture of undecatungstosilicate ([SiW11O39]8−) and Fe2+ (or Cu2+) also gave a good result, but their catalytic activities for producing ·OH (or 1O2) were rather weak. An electron microscopic study showed that almost nothing was visible on the surface of a biofilm-coated glass after treatment with 1mM [PW11O39]7−+1 mM Fe2+ and 500 mM H2O2 (incubated for 1 h at 37 °C).

• 公益社団法人　日本薬学会の論文

著者

• Tajima Yutaka

  Department Of Legal Medicine And Molecular Genetics Gunma University Graduate School Of Medicine

• Tajima Yutaka

  Legal Medicine and Molecular Genetics, Postgraduate School of Medicine, Gunma University

• Takagi Rie

  Legal Medicine and Molecular Genetics, Postgraduate School of Medicine, Gunma University

• Nakajima Tamiko

  Legal Medicine and Molecular Genetics, Postgraduate School of Medicine, Gunma University

• Yasuda Toshiro

  Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, Fukui University

• Kominato Yoshihiko

  Legal Medicine and Molecular Genetics, Postgraduate School of Medicine, Gunma University

• Kominato Yoshihiko

  Legal Medicine And Molecular Genetics Postgraduate School Of Medicine Gunma Univ.

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• 11-Tungstophosphate with Iron(II) and Hydrogen Peroxide Efficiently Detached Bacterial Biofilm

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