Advanced Glycation End Products in Patients with Cerebral Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Objective Oxidative modification of carbohydrates and lipids enhances the formation of advanced glycation end products (AGEs), which are formed not only in hyperglycemia, but also in normoglycemia. In this study, we determined skin AGEs in patients with cerebral infarction. Patients and Methods We non-invasively measured skin autofluorescence (AF) levels in patients with chronic cerebral infarction (CCI; n=95), patients with silent brain infarction (SBI; n=40), and age-matched controls (n=34), using an AGE Reader. Results Skin AF levels in patients with CCI and SBI were significantly increased compared with those in the control group (2.06±0.38, 2.16±0.47 and 1.84±0.35, respectively). Angiotension receptor blocker (ARB) or statins had no significant effect on the level of advanced glycation in any of the groups. Conclusion Our data suggest that increased formation of AGEs may be an indicator of oxidative stress, not only in diabetes and renal failure, but also in chronic cerebral ischemia.
著者
-
Takizawa Shunya
Division Of Neurology Department Of Internal Medicine Tokai University School Of Medicine
-
Takagi Shigeharu
Division of Hematology, Department of Internal Medicine, Tokai University School of Medicine
-
Miyata Toshio
Division of Translational Medicine, Center for Translational and Advanced Animal Research on Human Disease, Tohoku University School of Medicine
-
Ohnuki Yuko
Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine
-
Nagano Reiko
Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine
関連論文
- Intra-Arterial Fibrinolysis via the Contralateral Internal Carotid Artery for Acute Ischemic Stroke
- Administration of hematopoietic cytokines increases the expression of anti-inflammatory cytokine (IL-10) mRNA in the subacute phase after stroke
- Crossed Pontine Infarction Caused by Vertebro-basilar Artery Dissection
- Advanced Glycation End Products in Patients with Cerebral Infarction
- Ten Centimeter Elevation of the Contralateral Leg is Enough to Evaluate Hoover Sign
- Hemorrhagic Infarction in Tuberculous Meningitis
- An Atypical Form of Asian Variant of Intravascular Large B-cell Lymphoma Presenting with Myelopathy Alone for 4 Months Prior to Pancytopenia
- MR Findings in Call-Fleming Syndrome
- Syringomyelia in Neuromyelitis Optica Seropositive for Aquaporin-4 Antibody
- Response Letter Regarding the Article "Significance of the Presence of Metabolic Syndrome in Patients with Asymptomatic Arteriosclerosis Affecting the Aorta and the Cerebral, Extra-cranial Carotid and Coronary Arteries"