Insertion Testing of Polyethylene Glycol Microneedle Array into Cultured Human Skin with Biaxial Tension
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概要
- 論文の詳細を見る
Aiming at the practical use of polyethylene glycol (PEG) microneedles for transdermal drug delivery system (DDS), a testing apparatus for their insertion into cultured human skin has been developed. To simulate the variety of conditions of human skin, biaxial tension can be applied to the cultured human skin. An adopted testing scheme to apply and control the biaxial tension is similar to the deep-draw forming technique. An attention was also paid to the short-time setup of small, thin and wet cultured skin. One dimensional array with four needles was inserted and influence of tension was discussed. It was found that tension, deflection of skin during insertion and original curvature of skin are the important parameters for microneedles array design.
- 一般社団法人 日本機械学会の論文
著者
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Tachikawa Hiroto
Department Of Materials Chemistry Faculty Of Engineering Hokkaido University
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Takano Naoki
Department Of Manufacturing Science Osaka University
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Miyano Takaya
Department Of Micro System Technology Ritsumeikan University
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NISHIYABU Kazuaki
Department of Mechanical Engineering, Osaka Prefectural College of Technology
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NISHIYABU Kazuaki
Department of Industrial Systems Engineering, Osaka Prefectural College of Technology
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