Morphological Alterations of Submandibular Glands Caused by Cisplatin in the Rat

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概要

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• Cisplatin is a platinum-containing antineoplastic agent, widely used in the treatment of various malignant neoplasms including head and neck cancer. In this study we examined ultrastructural changes of rat submandibular glands (SMGs) after cisplatin treatment. Male Wistar rats aged 8 weeks were used in the experiments. Cisplatin was injected intraperitoneally into the rats (5 mg/kg/day) for three consecutive days. After 1, 3, 5, and 7 days, the SMGs were removed and observed under an electron microscope. The terminal portion of the SMG is seromucosal. Acinar cells contained a parallel array of rough-surfaced endoplasmic reticulum in the basal cytoplasm, and the apical cytoplasm was filled with homogeneous secretory granules. Vacuolation of cells was observed on the first day after cisplatin treatment. On the third and fifth days, the rough-surfaced endoplasmic reticulum showed an irregular arrangement. Mitochondrial swelling, and the presence of autophagolysosomes was also confirmed. On the seventh day, the damage to organelles began to decrease and the SMG exhibited a tendency towards improvement.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• KITASHIMA SADAHARU

  Department of Anatomy, Kurume University School of Medicine

関連論文

• An Anomalous Case of the Left Gastric Artery, the Splenic Artery and Hepato-Mesenteric Trunk Independently Arising from the Abdominal Aorta
• Morphological Alterations of Submandibular Glands Caused by Cisplatin in the Rat

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