The proteasome: Overview of structure and functions

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概要

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• The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells. The highly organized proteasome plays a prominent role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions, which has appreciably contributed to our understanding of cellular life. Many questions, however, remain to be elucidated.<BR><BR>(Communicated by Takao SEKIYA, M.J.A.)

• 日本学士院の論文

著者

• TANAKA Keiji

  Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science

関連論文

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• The proteasome: Overview of structure and functions
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