The catecholamine system in health and disease : —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes—

スポンサーリンク

概要

• 論文の詳細を見る

• Catecholamines [dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine); CAs] are neurotransmitters in the central and peripheral nervous systems as well as hormones in the endocrine system. CAs in the brain play a central role in versatile functions as slow-acting neurotransmitters functioning in synaptic neurotransmission, modulating the effects of fast-acting neurotransmitters such as glutamate and γ-aminobutyric acid (GABA). In this review, I focus on recent advances in the biochemistry and molecular biology of the CA system in humans in health and disease, especially in neuropsychiatric diseases such as Parkinsons disease (PD), in relation to the biosynthesis of CAs regulated by a pteridine-dependent monooxygenase, tyrosine 3-monooxygenase (tyrosine hydroxylase, TH) and its pteridine cofactor, tetrahydrobiopterin (BH4). (Communicated by Tamio YAMAKAWA, M.J.A.)

• 日本学士院の論文

著者

• NAGATSU Toshiharu

  Nagoya University Research Institute of Environmental Medicine

関連論文

• The catecholamine system in health and disease : —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes—

スポンサーリンク