Molecular devices for high fidelity of DNA replication and gene expression

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概要

• 論文の詳細を見る

• Certain types of DNA lesions, produced through cellular metabolic processes and also by external environmental stresses, are responsible for the induction of mutations as well as of cancer. Most of these lesions can be eliminated by DNA repair enzymes, and cells carrying the remaining DNA lesions are subjected to apoptosis. The persistence of damaged bases in RNA can cause errors in gene expression, and the cells appear to possess a mechanism which can prevent damaged RNA molecules from entering the translation process. We have investigated these processes for high fidelity of DNA replication and gene expression, by using both biochemical and genetic means. We herein describe (1) the molecular mechanisms for accurate DNA synthesis, (2) mammalian proteins for sanitizing the DNA precursor pool, (3) error avoidance mechanisms for gene expression under oxidative stress, and (4) the roles of DNA repair and apoptosis in the prevention of cancer.(Communicated by Takao SEKIYA, M.J.A.)

• 日本学士院の論文

著者

• Sekiguchi Mutsuo

  Fukuoka Dental College

関連論文

• ROLES OF DNA REPAIR METHYLTRANSFERASE IN MUTAGENESIS AND CARCINOGENESIS
• Molecular devices for high fidelity of DNA replication and gene expression
• Radiation Biology in the Post-genome Era

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