Involvement of mast cells in acute hepatic injury induced by galactosamine and lipopolysaccharide in mice

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated the possible involvement of mast cells in acute hepatic injury induced by galactosamine (GalN, 20 mg/mouse) and lipopolysaccharide (LPS, 15 ng/mouse) (GalN/LPS) in mice. Histidine decarboxylase (HDC) mRNA expression in the liver as well as serum ALT level was increased with time after GalN/LPS treatment. Steroid anti-inflammatory agent (dexamethasone), histamine H1 receptor antagonists (diphenhydramine and pyrilamine), histamine H2 receptor antagonists (cimetidine and ranitidine) and 5-HT2 receptor antagonist (ketanserin) were effective in reducing the ALT level at 8 h after the treatment with GalN/LPS. Furthermore, dexamethasone, diphenhydramine and cimetidine inhibited the increase in hepatic HDC mRNA level. The increase in ALT level by GalN/LPS was much lower in mast cell-deficient mice than in the congenic normal mice. Diphenhydramine further inhibited ALT level in response to GalN/LPS in mast cell-deficient mice. Our data suggest that mast cells play an important role in the development of hepatic injury induced by GalN/LPS, and suggest that histamine and 5-HT released from mast cells and other cells are involved in this model.(Communicated by Masanori OTSUKA, M. J. A., June 10, 2003)

• 日本学士院の論文

著者

• Abe Kazuki

  Pharmacological Research Department Research Laboratory Minophagen Pharmaceutical Co. Ltd.

• Inoue Hideo

  Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.

• Sato Toshitsugu

  Pharmacological Research Department Research Laboratory Minophagen Pharmaceutical Co. Ltd.

• Abe Kazuki

  Pharmacological Research Department Minophagen Pharmaceutical Co. Ltd.

• YOSHIDA Tsuyoshi

  Pharmacological Research Department, Research Laboratory Minophagen Pharmaceutical Co., Ltd.

• INOUE Hideo

  Pharmacological Research Department, Research Laboratory Minophagen Pharmaceutical Co., Ltd.

関連論文

• The inhibition of apoptosis by glycyrrhizin in hepatic injury induced by injection of lipopolysaccharide / D-galactosamine in mice
• Purification and Characterization of Thrombopoietin
• 217 CHRONIC EXPOSURE EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN 6 IN MICE
• Thrombin-Stimulated Proliferation of Cultured Human Synovial Fibroblasts Through Proteolytic Activation of Proteinase-Activated Receptor-1
• Synthesis and Inhibitory Effect of Novel Glycyrrhetinic Acid Derivatives on IL-1β-Induced Prostaglandin E_2 Production in Normal Human Dermal Fibroblasts
• Involvement of mast cells in acute hepatic injury induced by galactosamine and lipopolysaccharide in mice
• Identification of the α isoform of preprotachykinin-A mRNA in synovial fibroblasts isolated from patients with rheumatoid arthritis

スポンサーリンク