Ovalocytosis without band 3 gene 27-bp deletion and malaria infection

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概要

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• Genetic adaptation to malaria is a longstanding research topic in anthropology and human genetics. Southeast Asian ovalocytosis (SAO) has been documented to have resistance to malaria; however, the implications of existing data are controversial. In particular, SAO resistance to malaria is unlcear in terms of the types of SAO, with/without the 27-base pair deletion in the band 3 gene (B3Δ27). To shed light on the relationships between SAO and malaria, we surveyed Plasmodium infection, erythrocyte morphology, and the presence of the B3Δ27 among the residents of a selected area in East Kalimantan, Indonesia where malaria is endemic. We screened peripheral blood smears (n = 128) for Plasmodium infection and erythrocyte morphology under a microscope, and then DNA was extracted from the smears to be used as a template for a polymerase chain reaction to detect the B3Δ27. The prevalence of infection with Plasmodium including Plasmodium vivax and Plasmodium falciparum was approximately 30%. Among a total of 128 subjects, 9.4% and 18.0% showed moderate (ovalocytic cells: 30–49%) and severe (ovalocytic cells: 50–100%) ovalocytosis, respectively. A total of three B3Δ27 carriers were identified. The data set was statistically analyzed and we observed that (1) higher ovalocytic rate resulted in lower malaria infection and (2) the B3Δ27 did not prevent malaria infection. These results suggest that resistance of SAO to malaria is due to SAO without the B3Δ27.

• 日本人類学会の論文

著者

• Kimura Masako

  Unit Of Human Biology And Genetics Department Of Biological Sciences Graduate School Of Science The

• Ishida Takafumi

  Unit Of Human Biology And Genetics Department Of Biological Sciences Graduate School Of Science Univ

• Siswanto Jo

  Health Center Waingapu

• Soemantri Augustinus

  Department Of Child Health Faculty Of Medicine Diponegoro University

• ISHIDA TAKAFUMI

  Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo

関連論文

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• Distribution of a 27-bp deletion in the band 3 gene in South Pacific islanders
• Serological Survey for the Infection of Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus and Human T-Lymphotropic Virus-1 among Isolated Ethnic Groups in Nepal
• Ovalocytosis without band 3 gene 27-bp deletion and malaria infection
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• TP53 codon 72 polymorphism in 12 populations of insular Southeast Asia and Oceania
• The Pacific lineage (2E) of JC polyomavirus is prevalent in Sumba Island, Eastern Indonesia
• Ovalocytosis without band 3 gene 27-bp deletion and malaria infection
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