Itraconazole Oral Solution Enhanced Vincristine Neurotoxicity in Five Patients with Malignant Lymphoma
スポンサーリンク
概要
- 論文の詳細を見る
To prevent fungal infections in patients undergoing treatment for hematological malignancies, we investigated the use of oral itraconazole solution as opposed to itraconazole or fluconazole capsules. Herein, we report five lymphoma patients with severe vincristine neurotoxicity in strong association with oral itraconazole solution. Four patients suffered from severe myalgia with or without arthralgia which clinically resembled polymyalgia rheumatica. Two patients suffered from constipation due to subileus and one patient had a severe paralytic ileus. Appropriate management of the above symptoms, which included discontinuation of oral itraconazole solution, resulted in rapid recovery from neurotoxicity. Given the more consistent plasma concentrations of oral itraconazole solution when compared to itraconazole capsules and the ability of itraconazole to interfere with hepatic vincristine metabolism, we strongly recommend avoiding the combined administration of oral itraconazole solution and vincristine.
- 社団法人 日本内科学会の論文
著者
-
KAMEOKA Yoshihiro
Division of Hematology and Nephrology, Department of Internal Medicine, Akita University School of M
-
TAKAHASHI Naoto
Division of Hematology and Nephrology, Department of Internal Medicine, Akita University School of M
-
FUJISHIMA Naohito
Division of Hematology and Nephrology, Department of Internal Medicine, Akita University School of M
-
HIROKAWA Makoto
Division of Hematology and Nephrology, Department of Internal Medicine, Akita University School of M
-
SAWADA Kenichi
Division of Hematology and Nephrology, Department of Internal Medicine, Akita University School of M
-
Saito Hirofumi
Division Of Cardiology Brain Institute Niigata University School Of Medicine
-
Scott Stuart
Department Of Genetics And Genomic Sciences Mount Sinai School Of Medicine
-
Fujishima Masumi
Division of Hematology and Oncology, Department of Internal Medicine, Akita University School of Medicine
-
Kameoka Yoshihiro
Division of Hematology and Oncology, Department of Internal Medicine, Akita University School of Medicine
-
Yamanaka Yasuo
Division of Hematology and Oncology, Department of Internal Medicine, Akita University School of Medicine
-
Ubukawa Kumi
Division of Hematology and Oncology, Department of Internal Medicine, Akita University School of Medicine
-
Saito Kunie
Division of Hematology and Oncology, Department of Internal Medicine, Akita University School of Medicine
関連論文
- A case of intravascular large B-cell lymphoma of the cutaneous variant : the first case in Asia
- Prolonged Reactivation of Cytomegalovirus Infection following Successful Rituximab Therapy for Epstein-Barr Virus-Associated Posttransplantation Lymphoproliferative Disorder
- Late-Onset Fatal Epstein-Barr Virus-Associated Hemophagocytic Syndrome following Cord Blood Cell Transplantation for Adult Acute Lymphoblastic Leukemia
- Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma
- Vaginal Outflow Tract Obstruction Associated with Chronic Graft-versus-Host Disease Following Allogeneic Peripheral Blood Stem Cell Transplantation
- Successful Reduced-Intensity Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome with Severe Coronary Artery Disease
- Two karyotypically unrelated clones with 5q- and 20q- in a primary myelodysplastic syndrome patient evolving into acute nonlymphocytic leukemia
- Risk Factors for Severe Coronary Artery Disease - A Case-Control Study of Patients Who Have Undergone Coronary Artery Bypass Grafting
- Tumor-Derived TGFβ-1 Induces Dendritic Cell Apoptosis in the Sentinel Lymph Node
- Modulation of allogeneic immune responses by filgrastim (recombinant human granulocyte colony-stimulating factor) in bone marrow transplantation
- Mast cell leukemia with rapidly progressing portal hypertension
- Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia
- Itraconazole Oral Solution Enhanced Vincristine Neurotoxicity in Five Patients with Malignant Lymphoma