Improved Cardio-Respiratory Fitness Correlates with Changes in the Number and Size of Small Dense LDL: Randomized Controlled Trial with Exercise Training and Dietary Instruction
スポンサーリンク
概要
- 論文の詳細を見る
Objective To investigate the correlation between lifestyle improvements, in particular increased cardio-respiratory fitness and changes in the blood lipid profile. Methods The participants were 217 residents of Fuji and Yamato Towns, Saga City, with mildly abnormal blood pressure, serum lipids or blood glucose detected at health check-ups in 2003. Participants were randomly allocated to an Intervention (108 subjects) or Control group (109 subjects), matched for age and various conditions. The Intervention group was given exercise advice and prescription and dietary instructions. Cardio-respiratory fitness was evaluated using the work rate at double product breaking point. Changes of lipid parameters were compared before and after intervention, and examined the relationship with cardio-respiratory fitness. Results Seventy nine subjects in each group could be followed up for 17 months without requiring pharmacotherapy. Body mass index, waist circumference, systolic blood pressure, homeostasis model assessment insulin resistance, and triglycerides were decreased in the Intervention group. Furthermore, apolipoprotein B levels were lower (p<0.05), and the ratio of LDL cholesterol to apolipoprotein B (LDL/ApoB) was higher (p<0.001). When all subjects were divided into 3 subgroups according to the degree of improvement in cardio-respiratory fitness, LDL/ApoB increased and apolipoprotein B decreased as the degree of improvement increased (p<0.05). Conclusion Improvement was seen in atherosclerotic risk factors through lifestyle modification. In particular, improved cardiorespiratory fitness was associated with qualitative and quantitative changes in LDLs.
著者
-
Shono Naoko
Institute of Lifestyle Medical Science
-
Hirano Tsutomu
The first Department of Internal Medicine, Showa University School of Medicine
-
Yamaguchi Miyuki
Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science
-
Hisatomi Akitaka
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
-
Yoshimura Toru
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
-
Hisatomi Akitaka
Department of Internal Medicine, Saga University
-
Kawano Masayo
Department of Internal Medicine, Saga University
関連論文
- OJ-202 Effects of Acarbose and Nateglinide on Postprandial Hyperglycemia-Induced Endothelial Dysfunction : A Placebo Controlled Study(Diabetes/Obesity/Metabolic syndrome-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-337 The Mild Intensity Exercise Therapy Reduces Postprandial Glucose and Triglyceride Levels Even after Normal Fat Meal in Obese Subjects(Exercise test/Cardiac rehabilitation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-059 Small, Dense LDL Cholesterol is Useful for the Marker of the Metabolic Syndrome in Patients with Coronary Artery Disease(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- Postprandial Changes in LDL Phenotypes in Patients with Myocardial Infarction(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Significance of Small Dense Low-Density Lipoprotein-Cholesterol Concentrations as Angiographic and Clinical Severity of Coronary Heart Diseases (Atherosclerosis, Clinical 13 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- EVALUATION OF EXERCISE PRESCRIPTION BASED ON THE HEART RATE AND WORK RATE AT THE LACTATE THERSHOLD IN OBESE SUBJECTS WITH AND WITHOUT HYPERTENSION(Proceedings of The 8^ Asian Federation of Sports Medicine Congress 2005 Tokyo)
- 2B-06 There is possibility that relative working muscular ischemic threshold tension is the ergometoric measurement which is useful for angiogenesis around type II fiber(Muscular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Ex
- 2B-05 Regulation of gene expression in human skeletal muscle by short-term lactate threshold intensity exercise training(Muscular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- Effect of Low Intensity Aerobic Training on Skeletal Muscle Capillary and Blood Lipoprotein Profiles
- 1A-03 Relationships between the skeletal muscle morpology and the serum profiles of lipid and glucose metabolism in healthy Japanese men.
- Associations of monocytes, neutrophil count, and C-reactive protein with maximal oxygen uptake in overweight women
- PJ-504 Evaluation of the Required Exercise Duration Per Week to Improve the Blood Pressure and Serum Sodium/Potassium Ratio in Obese Subjects(Exercise test/Cardiac rehabilitation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- PJ-115 Effect of the Exercise on the Monocyte and Neutrophil Counts in Obese Women(Exercise test/Cardiac rehabilitation-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Association between Maximal Oxygen Uptake and the Heart Rate Corrected-QT Interval in Postmenopausal Overweight Women
- Detection of Sulfated Peptides as Their Onium Salts in the Positive Mode by MALDI-TOF Mass Spectrometry
- Transforming growth factor-β1-induced apoptosis is blocked by β1-integrin-mediated mitogen-activated protein kinase activation in human hepatoma cells
- Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1
- Bleeding and stenosis caused by reflux esophagitis was not common in emergency endoscopic examinations : a retrospective patient chart review at a single institution in Japan
- Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease
- The Relationship between Insulin Resistance and Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Patients with Coronary Artery Disease
- Population-based study of hepatitis C virus infection and hepatocellular carcinoma in western Japan
- Differential expression of laminin α chain in human hepatocellular carcinoma: a switch from α2 to α3 chain
- Improved Cardio-Respiratory Fitness Correlates with Changes in the Number and Size of Small Dense LDL: Randomized Controlled Trial with Exercise Training and Dietary Instruction
- Direct Detection and Comparison of Non-covalent Complex Formation of Oligo(tyrosine sulfate)s with Synthetic Heparin-binding Peptides by MALDI-TOF-MS
- Catalytic Use of Strontium Hexamethyldisilazide in the Asymmetric Michael Addition of Malonate to Chalcone Derivatives
- Analysis of Sulfo- and Phospho-Peptides as Quaternary Ammonium Salts by MALDI-TOF MS
- Solid Phase Synthesis, Characterization and Physical Properties of Oligo(tyrosine sulfate)s
- A Study on Interactions of Oligo(tyrosine sulfate)s with a Heparin-Binding Peptide by MALDI-TOF-MS
- Kenji Soda-researching enzymes with the spirit of an alpinist
- Decrease of Serum Ascorbic Acid Concentrations in Patients with Diabetic Macroangiopathy.