Investigation of Microalbuminuria in Nondiabetic, Normotensive Obese Women
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概要
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Aim To investigate if obesity which is not accompanied by diabetes and/or hypertension is associated with microalbuminuria in female patients. Materials and Methods A total of 77 obese female patients from the Outpatient Clinic of Endocrinology of Istanbul University Cerrahpasa Medical Faculty and 30 age-matched, lean, healthy women were enrolled in the study. Patients with accompanying diabetes mellitus, hypertension, obesity associated with any endocrine abnormality, hepatic or renal disease, fever, infectious disease, malignancy were excluded. Weight, height, body-mass index (BMI), waist circumference, waist/hip ratio (WHR) and systolic and diastolic blood pressures were recorded. Albumin excretion in 24-hour urine samples (UAE) were measured using SYNCHRON LX® System with MA Microalbumin kit in two separate 24-hour urine samples from every patient. Statistical analysis was performed using t-test and Pearsons correlation in SPSS 12.0 for Windows Program. Results The median albumin excretion in 24-hour urine sample was similar in obese and control groups (12.01 ± 10.69 mg/day vs 9.35 ± 4.09 mg/day; p= 0.211). There were no correlations between the albumin excretion in 24 hour urine samples and BMI, waist circumference, WHR, systolic or diastolic blood pressure. Conclusion Diabetes mellitus and hypertension are known to be associated with microalbuminuria. In our study, microalbuminuria was not detected in obese women without diabetes and/or hypertension and UAE was similar in obese and lean women.
著者
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Ugurlu Serdal
Department of Internal Medicine, Cerrahpata Medical Faculty, University of Istanbul
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Caglar Erkan
Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul
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Balci Huriye
Central Laboratory, Cerrahpasa Medical Faculty, University of Istanbul
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Yesim Tijen
Division of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul
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Ucgul Ayca
Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul
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Sarkis Cihat
Department of Medicine, Medical Faculty, University of Cumhuriyet
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Acbay Ozer
Division of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul
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Gundogdu Sadi
Division of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul
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Ugurlu Serdal
Department of Medicine, Medical Faculty, University of Cumhuriyet
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