Effects of Wu-chu-yu-tang and Its Component Herbs on Drug-Metabolizing Enzymes

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概要

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• The compound herbal medicine Wu-chu-yu-tang is used for the treatment of migraine and vomiting accompanying a cold. To assess the interactions of herb and drug metabolism, effects of Wu-chu-yu-tang on hepatic and renal cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT) and glutathione S-transferase (GST) were studied in C57BL/6J mice. Treatment of mice with 5 g/kg per day Wu-chu-yu-tang for 3 days caused 2.5-fold and 2.9-fold increases of liver microsomal 7-ethoxyresorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation activities, respectively. However, CYP activities toward 7-ethoxycoumarin, benzphetamine, N-nitrosodimethylamine, erythromycin and nifedipine, and conjugation activities of UGT and GST were not affected. In kidney, Wu-chu-yu-tang-treatment had no effects on Cyp, UGT and GST activities. Among the four component herbs of Wu-chu-yu-tang, only Evodiae Fructus (Wu-chu-yu) extract increased EROD activity and CYP1a2 protein level. In E. Fructus, rutaecarpine, evodiamine and dehydroevodiamine are the main active alkaloids. At the doses corresponding to their contents in Wu-chu-yu-tang, rutaecarpine-treatment increased hepatic EROD activity, whereas evodiamine and dehydroevodiamine had no effects. These results demonstrated that ingestion of Wu-chu-yu-tang elevated mouse hepatic Cyp1a2 activity and protein level. E. Fructus and rutaecarpine contributed at least in part to the CYP1a2 induction by Wu-chu-yu-tang. Patients should be cautioned about the drug interaction of Wu-chu-yu-tang and CYP1A2 substrates.

• 社団法人 日本薬理学会の論文
• 2002-07-01

著者

• DON Ming-Jaw

  National Research Institute of Chinese Medicine

• CHEN Chieh-Fu

  Institute of Pharmacology, National Yang-Ming University

• Wang Shu-yun

  National Research Institute Of Chinese Medicine

• Wang Jong-jing

  Institute Of Bio-pharmaceutical Sciences National Yang-ming University

• UENG Yune-Fang

  National Research Institute of Chinese Medicine

• PENG Hsiao-Chi

  National Research Institute of Chinese Medicine

• Chen Chieh-fu

  Institute Of Bio-pharmaceutical Sciences National Yang-ming University

関連論文

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• High-performance liquid chromatographic determination of evodiamine in rat plasma : application to pharmacokinetic studies
• Effects of Wu-chu-yu-tang and Its Component Herbs on Drug-Metabolizing Enzymes
• AFLATOXIN B1 OXIDATION BY HUMAN CYTOCHROME P450s
• Induction of Hepatic Cytochrome P450s by the Herbal Medicine Sophora flavescens Extract in Rats : Impact on the Elimination of Theophylline

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