Effect of 6-Hydroxydopamine Treatment in the Area Postrema on Morphine-Induced Emesis in Ferrets

スポンサーリンク

概要

• 論文の詳細を見る

• To investigate the role of catecholamine release in emesis, we examined the effects of pretreatment with 6-hydroxydopamine (6-OH-DA) administered into the area postrema in morphine-induced emesis in ferrets. In the 6-OH-DA pre-treated animals, the latency to the first emetic response induced by morphine hydrochloride (1.0 mg/kg, s.c.) was significantly prolonged and the number of retches and emetic episodes was markedly reduced. In the medulla oblongata, the levels of dopamine and homovanilic acid were reduced by 6-OH-DA pretreatment. These results suggest that catecholamine release in the medulla oblongata, mainly dopamine release, may play an important role in morphine-induced emesis in ferrets.

• 2002-08-01

著者

• YOSHIDA Naoyuki

  Pharmacology & Microbiology Research Laboratories, Dainippon Pharmaceutical Co. Ltd.

• Yoshida Naoyuki

  Pharmacology & Microbiology Research Laboratories Drug Research Division Dainippon Pharmaceutica

• YOSHIKAWA Takashi

  Pharmacology & Microbiology Research Laboratories, Drug Research Division, Dainippon Pharmaceutical

関連論文

• Discovery of a Novel and Potent Human and Rat β_3-Adrenergic Receptor Agonist, [3-[(2R)-[[(2R)-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic Acid
• Effect of 6-Hydroxydopamine Treatment in the Area Postrema on Morphine-Induced Emesis in Ferrets

スポンサーリンク