Nitric Oxide Synthase Gene Therapy for Cardiovascular Disease
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概要
- 論文の詳細を見る
Gene therapy refers to the transfer of specific genes to the host tissue to intervene in a disease process, with resultant alleviation of the symptoms of a particular disease. Cardiovascular gene transfer is not only a powerful technique for studying the function of specific genes in cardiovascular biology and pathobiology, but also a novel and promising strategy for treating cardiovascular diseases. Since the mid-1990s, nitric oxide synthase (NOS), the enzyme that catalyzes the formation of nitric oxide (NO) from <sc>L</sc>-arginine, has received considerable attention as a potential candidate for cardiovascular gene therapy, because NO exerts critical and diverse functions in the cardiovascular system, and abnormalities in NO biology are apparent in a number of cardiovascular disease processes including cerebral vasospasm, atherosclerosis, postangioplasty restenosis, transplant vasculopathy, hypertension, diabetes mellitus, impotence and delayed wound healing. There are three NOS isoforms, i.e., endothelial (eNOS), neuronal (nNOS) and inducible (iNOS). All three NOS isoforms have been used in cardiovascular gene transfer studies with encouraging results. This review will discuss the rationale of NOS gene therapy in different cardiovascular disease settings and summarize the results of experimental NOS gene therapy from various animal models of cardiovascular disease to date.
- 2002-08-01
著者
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Miao Chao-yu
Department Of Pharmacology And Toxicology And The Neuroscience Program College Of Human Medicine Mic
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REN Jun
Department of Medical Oncology, Beijing Cancer Hospital, School of Oncology, Peking University
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CHEN Alex
Department of Pharmacology and Toxicology, and The Neuroscience Program, College of Human Medicine,
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Chen Alex
Department Of Pharmacology And Toxicology And The Neuroscience Program College Of Human Medicine Mic
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Ren Jun
Department Of Bioscience And Bioengineering Dalian University Of Technology
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Ren Jun
Department Of Pharmacology And Toxicology And The Neuroscience Program College Of Human Medicine Mic
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