Beneficial Effect of α-Tocopherol in Renal Ischemia-Reperfusion in Rats
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概要
- 論文の詳細を見る
We evaluated the effects of α-tocopherol (vitamin E) on the products of lipid peroxidation and serum creatinine levels in a rat model of renal ischemia-reperfusion. The animals were submitted to sham operation or renal ischemia-reperfusion, and they were pretreated with α-tocopherol or the vehicle saline. In four groups, we analyzed the lipid peroxidation products by measuring malondialdehyde and chemiluminescence levels. In the other three groups, we studied the serum creatinine levels after the procedures. In our study, the pretreatment with α-tocopherol reduced significantly the lipid peroxidation of renal cells and renal dysfunction induced by renal ischemia-reperfusion in rats.
- 社団法人 日本薬理学会の論文
- 2001-10-01
著者
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Rhoden Ernani
Post-graduation Course In Medical Clinical Federal University Of Rio Grande Do Sul/porto Alegre Clin
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Pereira-lima Luiz
Post-graduation Course In Medical Clinical Federal University Of Rio Grande Do Sul/porto Alegre Clin
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Rhoden Claudia
Departments Of Pharmacology Porto Alegre School Of Medical Sciences/santa Casa University Hospital
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TELOKEN Claudio
Departments of Surgery, Porto Alegre School of Medical Sciences/Santa Casa University Hospital
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LUCAS Marcio
Departments of Pharmacology, Porto Alegre School of Medical Sciences/Santa Casa University Hospital
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BELLO-KLEIN Adriane
Laboratory of Physiology, Federal University of Rio Grande do Sul
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Teloken Claudio
Departments Of Surgery Porto Alegre School Of Medical Sciences/santa Casa University Hospital
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Bello-klein Adriane
Laboratory Of Physiology Federal University Of Rio Grande Do Sul
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Lucas Marcio
Departments Of Pharmacology Porto Alegre School Of Medical Sciences/santa Casa University Hospital
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Rhoden Cláudia
Department of Pharmacology, Porto Alegre School of Medical Sciences/Santa Casa University Hospital