Glutamate Exacerbates Amyloid β1 : 42-Induced Impairment of Long-Term Potentiation in Rat Hippocampal Slices

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概要

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• Amyloid β (Aβ) is the principal constituent of senile plaques in Alzheimer’s disease patients. We investigated whether Aβ and glutamate affect long-term potentiation (LTP) in rat hippocampal slices. Pretreatment with 1 μM Aβ1 – 42 alone for 3 h slightly inhibited LTP; however, the potentiation was maintained for 60 min. Although the impairment was not observed by pretreatment with 30 μM glutamate alone for 3 h, pretreatment with Aβ1 – 42 and glutamate impaired LTP significantly. These results raise the possibility that neurotoxicity of Aβ is exacerbated by the enhancement of susceptibility to excitatory amino acids.

• 社団法人 日本薬理学会の論文
• 2002-02-01

著者

• Nakagami Yasuhiro

  Neuroscience And Immunology Research Laboratories Sankyo Co. Ltd.

• Oda Tomiichiro

  Neuroscience And Immunology Research Laboratories Sankyo Co. Ltd.

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• Glutamate Exacerbates Amyloid β1 : 42-Induced Impairment of Long-Term Potentiation in Rat Hippocampal Slices

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