Interleukin-6-producing Giant Cell Carcinoma of the Lung with Multicentric Castleman's Disease-like Presentation
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概要
- 論文の詳細を見る
We encountered a 59-year-old man with advanced lung cancer with multiple swollen lymph nodes. At autopsy the lung cancer was revealed as giant cell carcinoma. Microscopic examination showed no cancer cells, but there was polyclonal proliferation of plasma cells in the lymph nodes and in the bone marrow. In the kidneys, proliferation of mesangial matrices and mesangial cells was found. This presentation resembled multicentric Castleman's disease (MCD), in which interleukin-6 (IL-6) has a great role. Immunohistochemical staining was positive for IL-6 in cancer cells. This is the first reported case of an IL-6-producing giant cell carcinoma of the lung with MCD-like presentation.
- 社団法人 日本内科学会の論文
著者
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Higashikuni Yasutomi
Division Of Cardiology Mitsui Memorial Hospital
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Higashikuni Yasutomi
Division of Internal Medicine, Center for Respiratory Diseases, Mitsui Memorial Hospital
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Mori Masaya
Division of Pathology, Mitsui Memorial Hospital
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Kino Hiroyoshi
Division of Internal Medicine, Center for Respiratory Diseases, Mitsui Memorial Hospital
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