Anti-interleukin-6 Receptor Antibody (Tocilizumab) Treatment of Multicentric Castleman's Disease
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概要
- 論文の詳細を見る
We report three cases of multicentric Castleman's disease (MCD) successfully treated with anti-interleukin-6 receptor antibody (tocilizumab). Tocilizumab was administered intravenously at a dose of 8 mg/kg every 2 weeks. In each case, tocilizumab alleviated symptoms, including generalized fatigue, pyrexia, and alleviated biochemical abnormalities, including anemia, hypoalbuminemia, hypergammaglobulinemia, and increased C-reactive protein (CRP). Side effects included hypercholesterolemia, acute pyelonephritis, mild inflammation of the parotid glands, and upper respiratory system inflammation. Other severe side effects were not observed. These results indicate that tocilizumab is effective for the treatment of MCD. This is the first report on tocilizumab efficacy for Castleman's disease after approval for use for Castleman's disease.
- 社団法人 日本内科学会の論文
著者
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TSUTSUMI Akito
Clinical Immunology, Major of Biomedical Application, Graduate School of Comprehensive Human Science
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Ito Satoshi
Clinical Immunology Advanced Biochemical Applications Graduate School Of Comprehensive Human Science
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Sumida Takayuki
Clinical Immunology Advanced Biochemical Applications Graduate School Of Comprehensive Human Science
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Matsumoto Isao
Clinical Immunology Advanced Biochemical Applications Graduate School Of Comprehensive Human Science
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Goto Daisuke
Clinical Immunology Advanced Biochemical Applications Graduate School Of Comprehensive Human Science
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Suzuki Takeshi
Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Mamura Mizuko
Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Tsuboi Hiroto
Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Matsuyama Masashi
Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Tsutsumi Akito
Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Tsutsumi Akito
Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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