Optical Bioimaging : From Living Tissue to a Single Molecule : Optical Detection of Synaptically Induced Glutamate Transporter Activity in Hippocampal Slices
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概要
- 論文の詳細を見る
Since voltage-sensitive dyes (VSDs) change their optical properties in response to membrane potential changes, non-invasive optical measurements of membrane excitation using VSDs have been applied to various types of excitable tissue. This article deals with the authors’ recent work using this technique in addition to basic and technical information about VSD imaging. By applying this technology to hippocampal brain slices, we have found that astrocytes play indispensable roles in sequestering glutamate, maintenance of synaptic transmission, and neuronal survival. Finally, the potential of VSD imaging for drug development was discussed.
- 社団法人 日本薬理学会の論文
- 2003-11-01
著者
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Miyakawa Hiroyoshi
Laboratory Of Cellular Neurobiology School Of Life Science Tokyo University Of Pharmacy And Life Sci
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Miyakawa Hiroyoshi
Laboratory Of Cellular Neurobiology School Of Life Science Tokyo University Of Pharmacy And Life Sci
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NAKAMURA Takeshi
Calcium Oscillation Project, ICORP, Japan Science and Technology Corporation
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KAWAMURA Yoshinobu
Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life S
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Nakamura Takeshi
Calcium Oscillation Project Icorp Japan Science And Technology Corporation
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Kawamura Yoshinobu
Laboratory Of Cellular Neurobiology School Of Life Science Tokyo University Of Pharmacy And Life Sci
関連論文
- Fluo-3 as an Extracellular Ca^ Indicator : Warning on the Use of the Dye for Slice Preparations
- Expression of Group I Metabotropic Glutamate Receptors in Rat Hippocampal Cells in Culture and Their Characterization by Intracellular Calcium Ion Dynamics
- NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons
- Optical Bioimaging : From Living Tissue to a Single Molecule : Optical Detection of Synaptically Induced Glutamate Transporter Activity in Hippocampal Slices
- Effects of Mannitol on Ischemia-Induced Degeneration in Rat Hippocampus
- Optical Bioimaging : From Living Tissue to a Single Molecule : Preface