Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice
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概要
- 論文の詳細を見る
In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl4) (5 μl/kg, twice a week for 12 weeks). Met, when given orally in drinking water at an estimated daily dose of 25 or 50 mg/kg for 10 weeks starting 2 weeks after CCl4 challenge, protected against CCl4 hepatotoxicity. The results indicate that the hepatoprotection afforded by Met treatment at a dose of 25 mg/kg against CCl4 toxicity may at least in part be mediated by the enhancement of mitochondrial glutathione redox status.
- 社団法人 日本薬理学会の論文
- 2003-12-01
著者
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Mak Duncan
Department Of Biochemistry The Hong Kong University Of Science & Technology
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KO Kam-Ming
Department of Biochemistry, The Hong Kong University of Science & Technology
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POON Michel
Department of Biochemistry, The Hong Kong University of Science & Technology
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Ko Kam-ming
Department Of Biochemistry The Hong Kong University Of Science & Technology
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Poon Michel
Department Of Biochemistry The Hong Kong University Of Science & Technology
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CHIU Po-Yee
Department of Biochemistry, The Hong Kong University of Science & Technology
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Chiu Po-yee
Department Of Biochemistry The Hong Kong University Of Science & Technology
関連論文
- Altered Susceptibility to Ischemia-Reperfusion Injury in Isolated - Perfused Hearts of Short - Term Diabetic Rats Associated With Changes in Non-enzymatic Antioxidants
- Enhancement of Hepatic Glutathione Regeneration Capacity by a Lignan - Enriched Extract of Fructus Schisandrae in Rats
- Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice
- Schisandrin B Decreases the Sensitivity of Mitochondria to Calcium Ion-Induced Permeability Transition and Protects against Carbon Tetrachloride Toxicity in Mouse Livers(Pharmacology)