Hydrogen Peroxide Is an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans
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概要
- 論文の詳細を見る
Vascular endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide (NO), and a yet unidentified endothelium-derived hyperpolarizing factor (EDHF). Possible candidates for EDHF include epoxyeicosatrienoic acids, endothelium-derived K+ ions, and as we have recently identified, hydrogen peroxide (H2O2). Electrical communication between endothelial and smooth muscle cells through gap junctions has also been suggested to be involved in endothelium-dependent hyperpolarization. Among the above candidates, the H2O2 hypothesis well explains the pathophysiological interactions between NO and EDHF and re-highlights the physiological roles of the reactive oxygen species in endothelium-dependent vascular responses. This brief review summarizes our current knowledge about H2O2 as an EDHF, with special reference to its production by the endothelium, its action on membrane potentials and its pathophysiological roles.
- 社団法人 日本薬理学会の論文
- 2003-05-01
著者
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Matoba Tetsuya
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Matoba Tetsuya
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
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Matoba Tetsuya
Department Of Cardiovascular Medicine Kyushu University Graduate School Of Medical Sciences
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
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