Anorganic bovine bone and a silicate-based synthetic bone activate different microRNAs
スポンサーリンク
概要
- 論文の詳細を見る
Bio-Oss (BO), composed of anorganic bovine bone, is widely used in several bone regeneration procedures in oral surgery. PerioGlas (PG) is an alloplastic material that has been used for grafting of periodontal osseous defects since the 1990s. However, how these biomaterials alter osteoblast activity to promote bone formation is poorly understood. We attempted to address this question by using microRNA microarray techniques to investigate differences in translational regulation in osteoblasts exposed to BO and PG. By using miRNA microarrays containing 329 probes designed from human miRNA sequences, we investigated miRNAs whose expression was significantly modified in an osteoblast-like cell line (MG-63) cultured with BO vs PG. Three up-regulated miRNAs (mir-337, mir-200b, mir-377) and 4 down-regulated miRNAs (mir-130a, mir-214, mir-27a, mir-93) were identified. Our results indicated that BO and PG act on different miRNAs. Globally, PG causes activation of bone-forming signaling, whereas BO also activates cartilage-related pathways. (J. Oral Sci. 50, 301-307, 2008)
- 日本大学歯学部の論文
著者
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Ilaria Zollino
Department of Medical-Surgical Sciences of Communication and Behaviour, Section of Maxillofacial Surgery, University of Ferrara
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Annalisa Palmieri
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Furio Pezzetti
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Anna Avantaggiato
Department of Medical-Surgical Sciences of Communication and Behaviour, Section of Maxillofacial Surgery, University of Ferrara
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Luca Scapoli
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Marcella Martinelli
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Marzia Arlotti
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Elena Masiero
Department of Histology, Embryology and Applied Biology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation
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Carinci Francesco
Department of Medical-Surgical Sciences of Communication and Behaviour, Section of Maxillofacial Surgery, University of Ferrara