Multicentric peripheral ossifying fibroma

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概要

• 論文の詳細を見る

• Peripheral ossifying fibroma (POF) is a common solitary gingival growth thought to arise from the periodontal ligament. Though the etiology of POF remains unknown, some investigators consider it an inflammatory or reactive process, while others suggest it is a neoplastic process. In this report, we present and discuss a unique case of multicentric POF, affecting the maxillary and mandibular gingiva of a 49-year-old Caucasian female with meticulous oral hygiene and routine dental care. Though biopsy samples from multiple sites revealed similar histopathologic features, consistent with POF, the fact that there was a multicentric presentation is a unique phenomenon for this lesion. Multicentric lesions presenting in the oral and maxillofacial region are not typical, but have been observed in conditions associated with known genetic mutations, such as nevoid basal cell carcinoma syndrome (multiple odontogenic keratocysts), multiple endocrine neoplasia type II (multiple neuromas), neurofibromatosis (multiple neurofibromas) and Gardner syndrome (multiple neoplasms). This case is the first one to demonstrate that there may be a multicentric variant of POF that has not been previously recognized, and given the clinical presentation and multifocal nature of disease, the lesions in this patient are likely the result of genetic mutation(s) that predisposes to gingival soft tissue overgrowths containing mineralized product. (J. Oral Sci. 48, 239-243, 2006)

• 日本大学歯学部の論文

著者

• Shuler Charles

  Center For Craniofacial Molecular Biology University Of Southern California

• Kumar Satish

  Orofacial Pain and Oral Medicine Center, Division of Diagnostic Sciences, School of Dentistry, University of Southern California

• Ram Saravanan

  Orofacial Pain and Oral Medicine Center, Division of Diagnostic Sciences, School of Dentistry, University of Southern California

• Jorgensen Michael

  Clinical Dentistry, Division of Primary Oral Health Care, School of Dentistry, University of Southern California

• Sedghizadeh Parish

  Division of Diagnostic Sciences, School of Dentistry and Center for Craniofacial Molecular Biology, University of Southern California

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• Multicentric peripheral ossifying fibroma

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