Proliferative activity in oral salivary gland tumors: the role of PCNA and AgNOR assessed by a double staining technique

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概要

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• The aim of this study was to evaluate the role of PCNA and AgNOR in the assessment of salivary gland tumor proliferation using a double staining technique. Ten cases of pleomorphic adenoma (PA) and seventeen cases of adenoid cystic carcinoma (ACC) were examined. Numeric and morphometric parameters of AgNOR were evaluated and compared in PCNA-positive and PCNA-negative nuclei. There were statistically significant differences in AgNOR numbers, perimeters and contour indices between PCNA-positive and -negative nuclei in the PA samples. The ACC samples demonstrated significant differences only in the AgNOR areas. Our results show that in salivary gland tumors there is not always a relationship between proliferative activity evaluated by AgNOR numeric and morphometric parameters and PCNA immunostaining. (J. Oral Sci. 46, 87-92, 2004)

著者

• Rivero Elena

  Department of Oral Pathology, School of Dentistry, Minas Gerais Federal University

• Loyola Adriano

  Department of Oral Pathology, School of Dentistry, Uberlândia Federal University

• Ferreira de

  Department of Oral Pathology, School of Dentistry, Minas Gerais Federal University

• Tarquínio Sandra

  Department of Oral Pathology, School of Dentistry, Pelotas Federal University

• Caliari Marcelo

  Department of Pathology, Biological Science Institute, Minas Gerais Federal University

関連論文

• Proliferative activity in oral salivary gland tumors: the role of PCNA and AgNOR assessed by a double staining technique

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