Time- and Subunit-dependent Differential mRNA Expression of L-type Ca2+ Channel during Progression of Right Ventricular Hypertrophy
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the molecular basis for changes in L-type calcium channel (VLCC) density in ventricular hypertrophy, we analyzed the mRNA expression of all the subunits including the main subunit α1c and auxiliary subunits (α2δ, β2 and β3) composing VLCC in rat right ventricular hypertrophy (RVH) induced by monocrotaline injection. To test the hypothesis that the expression of each subunit might change differently during progression of RVH, leading to an altered electrophysiologic outcome for VLCC, we investigated the ratio of the mRNA level of each auxiliary subunit to the main subunit. After monocrotaline injection, α1c mRNA showed a transient decrease on the 14th day and thereafter significantly increased to reach approximately 1.8 fold that of the control level on the 21st day. The auxiliary subunit α2δ mRNA showed a pattern similar to that of α1c. The β3 mRNA increased rapidly after monocrotaline injection and increased approximately 4.1 fold. On the other hand, β2 mRNA showed no significant changes. Accordingly, only the mRNA ratio of β3 to α1c showed a significant increase among the auxiliary subunits after the monocrotaline injection. The ratio increased to a maximum of approximately 5.7 fold on the 14th day and thereafter decreased. These results suggest that VLCC density may be modified not only by α1c but also by its auxiliary subunit expression in ventricular hypertrophy, and provide a clue for understanding the controversial electrophysiologic results on VLCC density in hypertrophied hearts.
著者
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YAMASHITA Takeshi
The Cardiovascular Institute
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Hayami Noriyuki
the Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Omata Masao
the Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Murakawa Yuji
the Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Nakazawa Kiyoshi
Division Of Cardiology St. Marianna University School Of Medicine
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Miyake Fumihiko
Division Of Cardiology Department Of Internal Medicine St Marianna University School Of Medicine
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Nobuoka Sachihiko
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Hatano Seiji
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Fukui Eiichi
the Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Murayama Mashiro
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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