Immunoglobulin in Atherosclerotic Lesions of Human Aorta.

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概要

• 論文の詳細を見る

• An augmented expression of mRNA for IgG light chain was demonstrated age-dependently on atheromatous lesions of the aorta in Watanabe heritable hyperlipidemic (WHHL) rabbits. The present study was designed to determine factors related to inflammation in human vessels excised during surgery. We detected IgG mRNAs using RT-PCR in human atherosclerotic lesions but not in human umbilical arteries which have no atheromatous lesions. To determine the clonality of IgGs, cDNAs encoding variable regions of IgG heavy chain were examined using RT-PCR. Atherosclerotic lesions had several subtypes of IgG gene families' suggesting the involvement of polyclonal B-cells. mRNAs of interleukins-6 (IL-6), -1α (IL-1α), and -1β (IL-1β) were also detected in the same samples. In summary, inflammatory reactions were present in the atherosclerosis lesion.

• International Heart Journal刊行会の論文

著者

• Shiga Ryoko

  First Department of Internal Medicine, Yamagata University

• SHIGA Ryoko

  First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan

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• Immunoglobulin in Atherosclerotic Lesions of Human Aorta.

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