Hypoglycemia Induced by Interaction between Clarithromycin and Disopyramide.

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概要

• 論文の詳細を見る

• A 59-year-old man receiving hemodialysis was hospitalized due to severe hypoglycemic attack. The patient had been treated with disopyramide (50 mg/day) because of paroxysmal atrial fibrillation. Hypoglycemia occurred after taking clarithromycin (CAM, 600 mg/day), a macrolide antibiotic. The serum disopyramide concentration reached 8.0 μg/ml (23.6 μM) in the presence of CAM, while it was 1.5 μg/ml before the addition of CAM. A 75 g oral glucose tolerance test and daily profiles of blood glucose value showed that blood glucose levels were significantly lower in the presence of CAM and disopyramide compared to that in the absence of these drugs. The Turner index in the presence of CAM and disopyramide was significantly higher than that in the absence of these drugs, suggesting that a toxic concentration of disopyramide enhanced insulin secretion, resulting in the induction of hypoglycemic attacks, in which the inhibitory effects of CAM on the hepatic chytochrome P-450 might be involved. QT and QTc intervals were prolonged in the presence of CAM and disopyramide, but torsades de pointes were not observed in this patient receiving nicorandil (15 mg/day). Thus, it should be taken into account that life-threatening hypoglycemia may result from the interaction between clarithromycin and disopyramide.

• International Heart Journal刊行会の論文

著者

• Morita Toshihiro

  Second Department of Internal Medicine, University of Tokyo

• Toyo-oka Teruhiko

  Second Department Of Internal Medicine University Of Tokyo

• Nakajima Toshiaki

  Second Department Of Internal Medicine Graduate School Of Medicine University Of Toyama

• TOYO-OKA Teruhiko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

• IIDA Haruko

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

• SUZUKI Etsu

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

• IWASAWA Kuniaki

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

• MORITA Toshihiro

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

• NAKAJIMA Toshiaki

  Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

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